"In the last five years, the market for legal highs has exploded. It's never been easier, or cheaper, to buy drugs online – but no one knows what's in them, or how dangerous they are.
"Mephedrone was the perfect drug, wasn't it?" Ramsey says. "Water-soluble, not that toxic, and a very effective stimulant. Enormously enjoyable, users say, and very profitable for the dealers. People absolutely loved it. Well, they still do, actually – Britain is awash with the stuff."
Ramsey was among the first scientists to discover the chemical formula of mephedrone and is as conflicted as any rational observer over drug prohibition. "You can't just have shops and websites selling [legal highs] to kids. But it is the anti-drugs legislation, in many ways, that has prompted this innovation."
After mephedrone was banned, the dealers who had got rich quick cast around for new legal drugs that might capture the nation's imagination – and money. By 2010, the underground online drug culture had gone mainstream. None of the subsequent concoctions has gained the popularity of mephedrone, but the change it effected – of people looking online for legal drugs – is now permanent. Its significance is still playing out.
There is a market for these drugs when other drugs aren't very good. If there were good-quality coke, weed and pills, I don't know how much of a look-in these drugs would get."
The hidden dangers of legal highs - Guardian
Fascinating, scary article.